KTiller
Senior Poster
  
Offline
Posts: 355
Freeland, USA, usa, 51, 28, WA, Washington
Gender:
|
You might want to take a look at this article regarding "Steal Effect"; http://www.nature.com/jcbfm/journal/v21/n2/full/9591052a.html
Here's an except:
Intracerebral steal, a term popularized by Symon (Symon, 1968), refers to the paradoxical decrease of flow in the ischemic areas in response to vasodilator stimuli (Brawley et al., 1967; Hoedt et al., 1967). This behavior is attributed to shunting of blood flow away from nonautoregulating ischemic areas by the action of normally reactive vessels. The term "steal" has been suggested to be misleading because the underlying mechanism is rooted in a decrease in perfusion pressure (Wade and Hachinski, 1987). The concept of steal has been questioned and attributed to other sources such as a decrease in arterial pressure (Gogolak et al., 1985). Clinical studies have shown that the phenomenon has an ephemeral nature and can be documented only in a small proportion of patients and only in limited areas (Nariai et al., 1998; Olesen and Paulson, 1971). Furthermore, the demonstration of the effectiveness of the "inverse steal," by attempting to increase the flow in ischemic areas by vasoconstriction on normally autoregulating brain regions, has not been straightforward in head-injured patients (Darby et al., 1988; Roberts et al., 1998).
I had a neurlogist take me off of Aggrenox (Dipyridamole) because he thought it might cause this steal effect in a Moyamoya brain. Kim
|